However, local hyperimmunoglobulinemia is also present in non-atopic (as defined by the allergy nomenclature [77]) patients, meaning that elevated specific IgE levels result from other pathways, such as (i) ILCs and epithelial-derived cytokines [1], (ii) entopy, namely, the localized allergic inflammation that cannot be systemically measured [78], or (iii) autoallergy, against endogenous autoallergens in models similar to atopy eczema [79] or chronic spontaneous urticaria [80]. The gene discussed is IGHE; the disease is allergic disease.