In patients with CRSsNP exhibiting a T1-predominant biomarker profile, a group of 126 different genes was found upregulated, most of which were highly associated with the regulation of cells producing IFN-γ and IFN-γ signaling [93], including IFNG gene and genes associated with IFN-γ productions [94,95], MHC-related molecules, T cell, NK cell- and CD8+ T cell-associated genes, and molecules implicated in acute inflammation and host defense [96,97]. Here, IFNG is linked to chronic rhinosinusitis without nasal polyps.