Serum EDN levels are significantly elevated in eosinophilic CRS compared with non-eosinophilic CRS or controls and correlate with polyp score (the nasal polyp score scale ranges from 0 (no polyp) to 4 (large polyps) for each nostril) and peripheral eosinophilia [126]. The gene discussed is RNASE2; the disease is congenital rubella syndrome.