The administration of RESV (5 mg/kg during the last 45 days of a 90-day hyperglycemic period) to male Wistar rats with STZ-induced T1DM reduced renal hypertrophy, structural changes (i.e., tubular atrophy, mesangial expansion or wrinkling, diffuse glomerulonephritis and fibrosis), the accumulation of AGEs, OS, DNA damage (8-OHdG) and 4-HNE, caspase-3 and cleaved caspase-3 levels, but not RAGE expression [130]. Here, CASP3 is linked to cardiac hypertrophy.