It has been found that RESV facilitates proteinuria, reduces the content of MDA, while increasing the activity of Mn-SOD in the renal cortex, inhibits the apoptosis of renal tubule glomerular podocytes and epithelial cells, improves pathological manifestations and restores the expression of the silencing information modulator 2 (sir2)-related enzyme 1 (SIRT1) and PGC-1α) in the kidney tissues of mice with DN [41]. The gene discussed is PPARGC1A; the disease is liver dysplastic nodule.