The daily oral administration of curcumin nanoparticles for 10 weeks, together with long-acting insulin, in rodent models of DN led to the significant suppression of renal NLRP3, IL-1β, NF-ĸB, Casp3 and MAPK8 mRNA levels, which indicated the normalization of inflammation and apoptosis pathways [148]. The gene discussed is INS; the disease is liver dysplastic nodule.