In a randomized, double-blind, placebo-controlled study on nanocurcumin consumption in patients with DM on hemodialysis, significant decreases in fasting glucose, insulin, TG, very-low-density lipoproteins (VLDLs), TC, LDL, CRP and MDA levels were found, along with significant increases in TAS plasma content [146]. Here, INS is linked to diabetes mellitus.