CRP and rheumatoid arthritis: On the other hand, significant differences between RA flare-up and remission patients were also found in the number of painful and swollen joints (p < 0.01, p < 0.01, respectively), level of discomfort and pain (p < 0.001, p < 0.001, respectively), evaluation of RA symptoms by the rheumatologist (p < 0.001), serum CRP levels (p < 0.01), and DAS28 (p < 0.0001) (Table 2).