MTHFR and preeclampsia: In two most recent large-scale GWAS analyses, MTHFR-CLCN6, NPR3, also called NPRC (encoding natriuretic peptide receptor C on 5p13), FURIN (15q26), and PGR (encoding the progesterone receptor on 11q22) were identified among 18 independent loci associated with gestational hypertension and preeclampsia [18,19].