IL6 and rheumatoid arthritis: Two multicenter randomized controlled trials called CAPRA-1 and -2 (Circadian Administration of Prednisone in RA) demonstrated that taking modified-release prednisone at 22:00 and releasing it around 2:00–3:00 more effectively diminished morning stiffness duration, joint pain, fatigue, and the serum IL-6 level compared with talking immediate-release prednisone in the morning [83,84].