In terms of epigenetic modulators, the increased expression of DNA methyltransferases 3A and 1 (DNMT3A and DNMT1) was observed in TGFβ–activated fibroblasts from fibrotic skin patients with systemic sclerosis (SSc), a prototypical idiopathic fibrotic disease. The gene discussed is TGFB1; the disease is systemic sclerosis.