In addition, it was proposed that RHOA is required for stiffness-mediated phosphorylation of AKT and EP300 and the concomitant transcription of more than 20 tumor-promoting factors, including CXCL12, IL11, IL6, VEGFA, PDGFA and PDGFB, FGF, and CTGF. Here, EP300 is linked to neoplasm.