By contrast, other miRNAs have anti-angiogenic role and appear reduced after MI such as miR-185-5p, miR-143 and miR-92a, which target CatK, IGF signaling pathway and integrin subunit alpha5 (ITGA5), respectively [106,107,108,109], or miR-24 that regulates PAK4, GATA2 [110], and eNOS [111], suggesting the use of encapsuled antagomiR as therapeutic strategy to improve angiogenesis and heart function after MI. This evidence concerns the gene NOS3 and myocardial infarction.