Other co-factors might be taken into consideration in cardiac angiogenesis given the high amount of research demonstrating an increase in pro-angiogenic paracrine/autocrine signals after MI due to the action of fibroblast growth factor 2 (FGF2), hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF), insulin growth factor-1 (IGF-1) [12,13,14,15,16], hormones (estradiol, estrogen, etc.)[17,18], interleukins 2, 6, 17 (IL2, IL6, IL17), transforming necrosis factor α (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) [19,20,21,22]. The gene discussed is IGF1; the disease is myocardial infarction.