Significant increase in the expression of ECs markers, CD31, was observed in antagomiR-19a-3p transfected mice’s hearts, as compared with non-transfected group after MI, suggesting that the administration of antagomiR-19a-3p enhanced angiogenesis and improved heart function in MI mice by modulating HIF-1α expression [95]. The gene discussed is PECAM1; the disease is myocardial infarction.