VEGFA and myocardial infarction: PTEN signaling pathway activation of angiogenesis was also regulated by miR-499-5p stimulated by Tanshionone IIA, the main active monomer compound of Danshen, injected in the peri-infarcted mice heart, which improved cardiac function after MI by increasing the expression of VEGF and angiotensin-1, activating angiogenesis [104].