APP and early-onset autosomal dominant Alzheimer disease: Salidroside extracted from R. rosea showed protective effects against Aβ-induced neurotoxicity in a Drosophila Alzheimer’s disease model [71] as well as in APP/PS1 mice Alzheimer’s disease model, where behavioral performance was improved, the soluble and insoluble Aβ levels decreased, levels of synapse-related proteins increased and, and PI3K/Akt/mTOR signaling upregulated [72].