Finally, since it is known that cell death is a common result of apoptosis, the APOE and APP activities were examined; B. bifidum novaBBF7 10 mg/mL, B. longum novaBLG2 5 mg/mL and L. paracasei TJB8 10 mg/mL was able to revert the damages induced under oxidative condition, demonstrating the probiotics’ active role in treating intestinal dysregulation, which can affect cell death and cognitive impairment. The gene discussed is APP; the disease is Cognitive impairment.