Similarly, pyrazolone derivatives (e.g., dipyrone, antipyrine, aminopyrine, and propyphenazone), used to provide acute relief in migraine attacks with an unclear mechanism of action, have been found to selectively antagonize TRPA1 both in vitro and in vivo, attenuating nociception and allodynia in animal models of neuropathic and inflammatory pain through a TRPA1-mediated mechanism (independently from prostaglandin production) [164,165]. This evidence concerns the gene TRPA1 and migraine disorder.