Mrc1 deficiency is associated with a decrease in circulating neutrophils and pro-inflammatory CCR2+ monocytes and low infiltration of these cells into tissues, against a background of increased presence of adipocytes in the BM in obese mice (Mrc1-/-) [80] (slowing the development of obesity) [79]. The gene discussed is CCR2; the disease is obesity due to melanocortin 4 receptor deficiency.