Neuronally expressed α7 nAChRs, which function mainly as ligand-gated ion channels play key roles in cellular signaling, and their dysfunction due to widespread expression of dupα7 is thought to be associated with several central nervous system disorders, including schizophrenia and certain forms of cognitive deficits (see reviews by Bertrand et al. (2015) and Bertrand and Terry (2017)) [32,33]. The gene discussed is CHRNA7; the disease is Cognitive impairment.