APP and Alzheimer disease: In any case it should be emphasized that, importantly, even with the time-dependent modulation of the extents of the relevant thresholds or the potential aging-related variability of the rate of accumulation of AβPP-derived iAβ, the dynamic aspects of the T0 and T1 crossings would remain subjects to the same logic as applied above and would be fully consistent with the proposed therapeutic strategies for AD and AACD discussed below.