The differential effects on CR can be deduced by comparing the WT and TG strains: in the former, interstitial fibrosis increased significantly more than the cardiac hypertrophy parameters in response to Ald infusion, whereas the change in the morphometric parameters was comparable in the setting of excess TGF-β1 (Figure 4 and Figure 5). The gene discussed is TGFB1; the disease is cardiac hypertrophy.