CD274 and cancer: Moreover, immunotherapy, which includes cancer vaccines, monoclonal antibodies and inhibitors of immune checkpoints such as anti-PD-1/PD-L1 and anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA4) [275,276], is promising in that it may revolutionise the treatment of cancer by inducing, enhancing or suppressing immune responses against cancer cells.