EGFR and colorectal neoplasm: For example, due to the reactivation of upstream receptor tyrosine kinases (RTKs), such as epidermal growth factor receptor (EGFR), BRAF-mutant colorectal tumours are resistant to BRAF inhibitors, while low levels of EGFR expression in BRAF-mutant melanomas were not affected by the negative feedback relief [35,36].