CD274 and hepatocellular carcinoma: For example, recent clinical trial results for unresectable HCC have shown that combination therapies, such as tremelimumab (anti-CTLA4 Ab) (HIMALAYA) + durvalumab (anti-PD-L1 Ab) + bevacizumab (anti-VEGF Ab) (IMbrave 150) + atezolizumab (anti-PD-L1 Ab) outperform monotherapy in terms of clinical outcomes [278,279].