Recent research has demonstrated that the abnormal expression of nerve growth factor receptor (NGFR), SRY-Box transcription factor 2 (SOX2), AXL RTK and melanocyte-inducing transcription factor (MITF) in melanoma cells make them more susceptible to shift into a persister state in response to RAF and MAPK inhibition [120,121]. This evidence concerns the gene SOX2 and melanoma.