Moreover, through the PTEN/Akt/SMAD2 and RAS/MEK/FOS MAPK/Akt pathways, the apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1)/miR-27a-5p axis contributed to the resistance to doxorubicin in gastric cancer cells [261]. This evidence concerns the gene AKT1 and gastric cancer.