VEGFA and neoplasm: Research has demonstrated that αvβ3 collaborates with growth factor receptors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF2) to promote angiogenic events, primarily mediated by the activation of matrix metalloproteinases (MMPs) and proteolytic degradation of the ECM, facilitating proliferation and migration of endothelial cells to the tumor site [8,11,15].