The downregulation of miR-199a-5p, miR-214-3p, miR-424-3p, miR-424-5p, and miR-125b-5p in PGR-negative serous tumors can lead to increased levels of MUC16, MMP7, and MMP9, thereby enhancing the migratory ability of ovarian cancer cells, facilitating their adhesion to secondary sites, and promoting metastasis [30]. The gene discussed is MUC16; the disease is ovarian carcinoma.