The same controversial results in the expression pattern between liver cancer and autoimmune liver diseases has been highlighted for hornerin; this protein was found to be elevated via proteomic analysis in hepatocellular carcinoma [57] while our proteomic data revealed hornerin as the only protein with levels reduced in both AIH and PBC patients with respect to HCs as well as the protein that, in RF analysis, best discriminated these pathologies from HCs. This evidence concerns the gene HRNR and hepatocellular carcinoma.