Clusterin was found to be upregulated in thioacetamide-induced and bile duct ligation mouse models of liver fibrosis; the upregulation of clusterin attenuated hepatic fibrosis by inhibiting the hepatic stellate cells’ activation and Smad3 signaling pathways responsible for the production of extracellular matrix proteins such as type I collagen [52]. The gene discussed is SMAD3; the disease is Hepatic fibrosis.