NMO is an autoimmune disease of the CNS in which binding of anti-aquaporin-4 (AQP4) autoantibodies (NMO-IgG) to astrocytes causes complement-dependent cytotoxicity (CDC) and inflammation causing demyelinating lesions cause optic neuritis and transverse myelitis [90,91]. Here, AQP4 is linked to neuromyelitis optica.