Additionally, signaling through other expressed immune checkpoints, such as cytotoxic T lymphocyte-associated protein 4 (CTLA-4), lymphocyte-activation gene 3 (LAG3) or T cell immunoglobulin and mucin domain 3 (TIM-3) suppresses the function of immune cells in the tumor microenvironment (TME) [5,6]. This evidence concerns the gene CTLA4 and neoplasm.