SETDB2 and neoplasm: Conversely, we found changes in methyltransferases implicated in K9 trimethylation in all tumor specimens: in particular, basalioma showed an upregulation of SETDB1, SETDB2, and SUV39H2; bladder cancer showed an upregulation of SETDB1; and head and neck cancer showed an upregulation of SUV39H2 and downregulation of SETDB2 (Figure 6b).