DDIT3 and osteoporosis: Bone marrow aspiration tests as part of the pretreatment staging studies are done to evaluate for potential bone marrow infiltration of lymphoma cells, and pretreatment BMD measurements are obtained as baseline levels, out of concern for exacerbation of osteoporosis caused by the corticosteroids that are included in standard anti-lymphoma therapies, such as R-CHOP and others.