Methylation changes in the HLA region and VMP1/MIR21 have been identified in Scottish children with CD [56], and, on the other hand, in adult IBD patients, in the RPS6KA2 and VMP1 and ITGB2 and TXK genes, respectively, differentially methylated positions (DMPs) and differentially methylated regions (DMRs) have been demonstrated [62]. This evidence concerns the gene VMP1 and inflammatory bowel disease.