Similarly, HSF1, which was demonstrated to prevent colitis in mice through the activation of HSP70 [31], seems to lose its protective role during the progression of inflammatory intestinal disorders playing a carcinogenic role within the cells [85] and when it is located in the extracellular matrix during the pre-malignant inflammatory stage; here, HSF1 promotes ECM remodeling [86]. Here, HSF1 is linked to colitis.