HSPA1A and cancer: The HSP70 family genes (HSP70-1, -2 and -Hom) are localized in the short arm of the human chromosome number six, close to the gene encoding for the human leukocyte antigen (HLA). The genotype of HSP70 has been related both to cancer and to a reduced risk of the gastric premalignant condition [46], demonstrating that the polymorphisms may be decisive for the protective or non-protective role of the encoded protein.