In the matter of IFN-γ response defects, the presence of multifocal osteomyelitis could indicate a partial autosomal dominant (AD) IFN-γR1, or partial autosomal recessive (AR) or partial AD STAT1, which results in loss of function in these genes [48,57]; additionally, patients presenting with an eradicated IFN-γ response, thus with a complete deficiency in IFN-γR1 and IFN-γR2, are more prone to viral diseases such as cytomegalovirus [57,58]. Here, IFNG is linked to Alzheimer disease.