In a study of pulvinar tissue from DLB cases where Lewy body neuropathology burden was low, whole transcriptome RNA sequencing identified several enriched pathways compared to controls, from which the authors focused on genes relating to positive immune system processes and validated these findings with the detection of higher protein levels of astrocyte markers (GFAP and YKL-40) and the cellular stress-associated molecule heat shock protein 70 1A (HSPA1A) in DLB [60]. This evidence concerns the gene HSPA1A and Lewy body dementia.