Clinical presentations with an absolute lymphocyte count >5 × 109/L, a clinical presentation characteristic of T-PLL, including characteristic skin lesions, splenomegaly, or effusions, and characteristic chromosomal abnormalities (Table 2), favor a diagnosis of TCL1-family negative T-PLL over PTCL, NOS with leukemic involvement. This evidence concerns the gene TCL1A and Splenomegaly.