Studies have shown that (1) intracellular ATRA is low within various cancer cells, (2) the enzymes required for ATRA synthesis are often absent, (3) RARγ is an oncogene for some cancers and transactivated by nM ATRA, (4) the miR-30a-5p is a tumor suppressor and expression is low in cancers that overexpress RARγ, and (5) the miR-30a-5p is a negative regulator of RARγ expression. The gene discussed is RARG; the disease is neoplasm.