Reduced mRNAs in most tumor samples included ADH4, ADHIB, ADHIC, and RDHL (for oxidation of all-trans retinol to all-trans retinaldehyde), and AKR1B10, AKR1B1, and RDH12 (for reduction of all-trans retinaldehyde to all-trans retinol). This evidence concerns the gene AKR1B10 and neoplasm.