As infiltrating macrophages are a cardinal feature of inflammation, ablation of SOCS3 in myeloid cells shows that STAT3 is constantly activated in the murine model of AMD and DR [9,317] while inhibition of STAT3 activation can partially reverse the phenotype of choroidal neovascularization in mice; this suggests the contributory role of STAT3/SOCS3 in the development of disease. This evidence concerns the gene SOCS3 and age-related macular degeneration.