In particular, increased signaling of IL-8, PDGF-A, TGF-beta 1, VEGF-A, and VEGF-C was reported in aneurysm samples in a previous studies; therefore, the changes in the circulatory levels of these factors shown in our study could probably reflect their increased signaling in aneurysm tissue. The gene discussed is TGFB1; the disease is aneurysm.