When a condition of obesity develops, macrophage infiltration in AT occurs, releasing a massive amount of pro-inflammatory cytokines, including interleukin (IL)-6 and tumor necrosis factor α (TNFα), with consequent induction of several pro-inflammatory pathways and JNK and nuclear factor–kappa B cells (NF-κB) [2,3,4]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.