Dysregulation of PPARγ can disrupt the balance between adipocyte differentiation and lipid storage, leading to hypertrophy (accumulation of triglycerides in enlarged adipocytes) and can alter the production and release of adipocytokines, leading to an imbalance between energy homeostasis and anti- and pro-inflammatory factors, irrevocably contributing to the impairment of AT functionality, a condition known as AT dysfunction (ATD) [9,11]. The gene discussed is PPARG; the disease is Jeune syndrome.