In particular, in T2D patients from Dataset 1, ANPEP correlated with ERP27 and RLN1, G6PD correlated with PGD and SSR1, PGD correlated with SSR1 and GFER, HSPA7 correlated with HSPB2, HSPB2 correlated with NDC1, RAE1 correlated with HERPUD1, MTOR correlated with GCLC and TNFRSF21, POM121C correlated with HERPUD1. The gene discussed is RLN1; the disease is type 2 diabetes mellitus.