Compared to non-diabetics, T2D patients were found to have decreased expression of genes regulating protein folding such as BAG3, NDC1, HSPA7, HSPB2, RLN1, and TNFRSF21 in Dataset 1, and HSP90AB1, HSPA1B, HSP90AA1, HSPA8, NUP160, ST13, and RPS19BP1 in Dataset 2. This evidence concerns the gene HSPA8 and type 2 diabetes mellitus.