In T2D samples of Dataset 2, GCLC influenced the expression levels of DNAJA2, HSPB1, NUP153, NUP58, TPR, and DNAJB1; GCLM influenced the expression of POM121C, RPA2, CREB3L4, EIF2S1, and PPP1R15A; and GSS influenced the expression of DNAJC7, HSPA1L, NUP160, RPA2, TPR, and DNAJB1. The gene discussed is EIF2S1; the disease is type 2 diabetes mellitus.