If we compared the urinary biomarker levels between IC/BPS and non-IC/BPS LUTD subgroups, patients with IC/BPS had a significantly higher level of eotaxin, MCP-1, TNF-α, 8-OHdG, and TAC; and a significantly lower level of CXCL10. This evidence concerns the gene CCL2 and Bartsocas-Papas syndrome 1.