Additionally, it was found that the combined treatment with 2-DG and sorafenib, an inhibitor of tyrosine protein kinases such as VEGFR, PDGFR, and the Raf family kinases, increased apoptosis and inhibited colony formation of the hepatocellular carcinoma cell line Hep3B and Huh7 cells [44]. Here, KDR is linked to hepatocellular carcinoma.