FBN1 and generalized lipodystrophy: A splicing mutation was also revealed by Horn et al. [14], who identified a novel heterozygous de novo splice site mutation c.8226þ1G > T, affecting the last intron of the fibrillin 1 (FBN1) gene in a patient with progeroid and lipodystrophic features, and similar results have been shown in reports concerning cases of generalized lipodystrophy [15,16].