Previous research demonstrated that ATF4 knockout (AlbCre) in the livers of mice on a 4 week-long Lieber–DeCarli diet resulted in resistance to the development of hepatosteatosis and among the key mechanisms by which ATF4 increased steatosis were increased lipogenesis, a lipid uptake gene signature, and increased AMPK activity [41]. This evidence concerns the gene ATF4 and steatosis.