CYP2E1 and steatosis: Our data show that even though the ETOH-BKO mice display higher steatosis levels and greater expression of the ISR network compared to the ETOH-WT mice, their blood ETOH levels and liver CYP2E1 protein levels are not higher (Supplementary Figure S2), suggesting that, in part, RARβ regulates cellular stress independently from CYP2E1.