HAVCR2 and acute myeloid leukemia: It was predicted that TIM3 (CD366), a member of the T cell immunoglobulin mucin (TIM) family, is a novel, important, and differentiating membrane surface marker for LSCs [76,77,78,79,80], a negative regulator of T helper1 (Th1) cells immunity [81], and a prognostic factor in patients with AML [74].