Histological features as well as established cell surface markers (progesterone receptor—PR, estrogen receptor—ER, and the human epidermal growth factor receptor 2—HER2), genomic markers (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha—PIK3CA, breast cancer gene 1—BRCA1, breast cancer gene 2—BRCA2), proliferation marker (Ki67), and immunomarkers (tumor-infiltrating lymphocytes, programmed death-ligand 1—PD-L1) are routinely used in the clinic for diagnosis [10]. Here, ESR1 is linked to neoplasm.