The overexpression of PTBP1 can induce cardiac hypertrophy and exacerbate cardiac fibrosis, either by disrupting alternative splicing or by reducing mRNA stability [102,103], while the knockdown of PTBP1 improves cardiac fibrosis in the MI-injured mouse heart, indicating a potential role in cardiac repair [102]. The gene discussed is PTBP1; the disease is myocardial infarction.