L-NGmethylarginine hydrochloride (546C88) (L-NAME), a non-specific NOS inhibitor, sumatriptan, and indomethacin, when administered as pre-treatment, can all inhibit TNC activation caused by NTG administration or electrical stimulation of the superior sagittal sinus (both experimental animal models of migraine) [67,71,75]. The gene discussed is NOS1; the disease is migraine disorder.