This miRNA has demonstrated anti-inflammatory properties in inflammatory models such as atherosclerosis [30], while it has also been shown to have pro-inflammatory effects in osteoarthritis [31] and ulcerative colitis [32], whereas hsa-miR-146a-5p may promote differentiation in dental stem cells by targeting Traf6 via the NF-κB signaling pathway [33]. This evidence concerns the gene NFKB1 and osteoarthritis.