INS and Hypoglycemia: Along with CGM, it had a significant technological development in recent years with the availability of integrated devices provided with algorithms that automatically suspend insulin infusion in case of current or predicted hypoglycemia (LGS or PLGS) to resume it when the hypoglycemia resolves or that adjust the basal insulin delivery rate based on glucose sensor data, leaving to the patient the administration of the bolus at mealtime, as in hybrid closed-loop systems.