In this report, for the first time, we describe that standardized BGE and its major ginsenosides (Rg3, Rg5, and Rk1) possess effective anti-asthmatic activity by showing a relationship between PKCθ and asthma-associated transcription factors in PMA/ionomycin-stimulated EL4 cells or OVA-exposed mice with allergic airway inflammation. This evidence concerns the gene PRRT2 and asthma.