AD is typified by synapse degeneration, primarily within the neocortex, accompanied by the accumulation of senile plaques comprising predominantly amyloid-beta (Aβ) deposits, as well as a neuronal element characterized by the proliferation of hyperphosphorylated tau proteins, neurofibrillary tangles, and neuroinflammation [2,3]. Here, MAPT is linked to Alzheimer disease.