To measure miRNA level changes in the HD model, we prepared small-RNA sequencing libraries from head samples of 5-day-old females expressing Htt.Q120 (HD samples) or Htt.Q25 (control samples) transgenes under the control of the pan-neuronal P{GawB}elavC155 (elav-GAL4) driver and subjected them to Illumina sequencing. Here, LGALS4 is linked to Huntington disease.