Additionally, while anergy would typically reduce the number of glucose transporters, we did not see a decrease in the GLUT1 in either the CD4+ or CD8+ ME/CFS T cell populations at rest; rather, the CD8+ T cells were able to upregulate GLUT1 at the same level in ME/CFS, compared to the control cells, after stimulatory factors were added [91]. Here, CD4 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.