ME/CFS cytokine observations also appear to agree with the senescence phenotypes, as SASP-like pro-inflammatory cytokines, such as TNFα, TGFβ, IL-1α, IL-1β, IL-4, IL-6, and IFNγ positively correlate with the ME/CFS disease severity; however, the overall analysis of cytokines in ME/CFS shows varying degrees of consistency [93,151,152,153,154,155]. Here, IL4 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.