PDPN and neoplasm: Hwang et al. [133] cited several studies in human and murine models, which highlight: (i) the crucial role of PDPN in TCIPA [134]; (ii) the strong association between PDPN-mediated TCIPA and the incidence of VTE in cancer patients [135]; and (iii) the association of PDPN with the occurrence of TCIPA, tumor growth and metastasis [131,136].