In addition to the anti-apoptotic interactions of TGF-β1 with tumor cells, platelet-derived TGF-β1 has also been reported in an earlier study as driving the transition of colon carcinoma and breast cancer cell lines to an invasive, mesenchymal-like phenotype, via the activation of Smad- and NFκB (nuclear factor κB)-dependent mechanisms [56]. This evidence concerns the gene TGFB1 and breast cancer.