These immunosuppressive effects of the cytokine result from the impairment of Tbet- and mTOR (mammalian target of rapamycin)-driven intracellular signaling mechanisms, resulting in defective degranulation and the release of the anti-tumor agents, granzyme B, perforin and IFN-γ [43,44,47,48]. Here, PRF1 is linked to neoplasm.