TGFB1 and lung carcinoma: The additional mechanisms of platelet-derived TGF-β1-driven epithelial-mesenchymal transition, which are broadly operative in various types of lung cancer cells, include epigenetic modifications, also involving the TGF and NFκB pathways, which result in DNA demethylation of the SNAIL1 and CD87 (urokinase receptor) genes [57].