APP and Alzheimer disease: An elegant study carried out on a novel APP knock-in mouse model (AppSAA) of AD with three mutations (Austrian, Swedish, and Arctic) in the mouse APP gene, showed significant alterations regarding lipid metabolism and disease-associated transcriptomic signature in the microglia containing a high amount of intracellular βA, consisting of vascular amyloid deposits, an accumulation of parenchymal amyloid plaques, alteration of astroglial and microglial functions, and an increase in CSF markers of neurodegeneration.