Several inflammatory proteins and genetic factors associated with innate immunity in AD, including Apolipoprotein E (APOE) and Triggering Receptor Expressed On Myeloid Cells 2 (TREM2), as well as Macrophage Migration Inhibitory Factor (MIF), soluble forms of TREM1, and TREM2 [51,52,53]. This evidence concerns the gene TREM2 and Alzheimer disease.