Although these immunohistochemical findings are naturally descriptive and a causal relationship remains speculative, the concomitantly observed ischemia-related alterations in vascular, extracellular and cytoskeletal elements, along with tricellulin, α-catenin and especially MFAP5, support the presumption that these elements may ensure cellular stabilization in the brain and may thus have a crucial role in the pathophysiology of stroke. This evidence concerns the gene MARVELD2 and Stroke.