Our research group has recently reported [73] that cytoplasmic overexpression of cyclin D1 in oral tumor cells is significantly associated with invasive morphology and the development of actin-based protrusive structures lamellipodia and invadopodia through sequential EGFR-cyclin D1-CDK4/6-paxillin-Rac1 activation, this being an oncogenic pathway that links an essentially proliferative pathway (EGFR) with the increased metastatic capacity of tumor cells. Here, CDK4 is linked to neoplasm.