EGFR and neoplasm: Constitutive oncogenic activation of EGFR is the main mechanism for the acquisition of one of the essential hallmarks of oral cancer, i.e., the ability of tumor cells to maintain a sustained proliferation [2,3,4], which in turn conditions the cells to enter a state of genomic instability that facilitates the acquisition of new additive oncogenic alterations, new hallmarks, which will be clonally transmitted to their progeny.