For this purpose, we used the cellular model of CRC progression composed of the isogenic lines SW480 (low metastatic) and SW620 (highly metastatic), from which we selected two FucT-8-deficient clones per line, obtained through stable knockdown with specific lentiviral shRNAs for the FUT8 gene encoding FucT-8 [41]. The gene discussed is FUT8; the disease is colorectal carcinoma.