Furthermore, glycosylation is also involved in tumour apoptosis, as suggested by the N-glycosylation sequence (Asn-X-Ser/Thr) at Asn156 of DR4 [23] and O-glycosylation sites harboured by DR5 [24], which could underpin its mechanistic involvement in TRAIL:death-receptor binding and/or receptor activation. This evidence concerns the gene TNFRSF10B and neoplasm.