In our study, we detected a reverse evolution of FucT-8 and PGP expression, especially in FUT8-knockdown clones derived from the SW480 line (Figure 3A,B), suggesting that FucT-8 hyperactivity in early CRC [20,51,65] may enhance resistance to apoptosis and thus contribute to malignant progression [60]. This evidence concerns the gene FUT8 and colorectal carcinoma.